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CSF1 & IL34 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Diabody) Human CSF1 IL34 Inquiry
T-BSDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Diabody) Human CSF1 IL34 Inquiry
SCIGG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scIgG) Human Single chain IgGs CSF1 IL34 Inquiry
SCIGG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scIgG) Human Single chain IgGs CSF1 IL34 Inquiry
FVTIG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv4-Ig) Human Appended IgGs CSF1 IL34 Inquiry
FVTIG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv4-Ig) Human Appended IgGs CSF1 IL34 Inquiry
BSSG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-IgG) Human Appended IgGs CSF1 IL34 Inquiry
BSSG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-IgG) Human Appended IgGs CSF1 IL34 Inquiry
IGLFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs CSF1 IL34 Inquiry
IGLFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs CSF1 IL34 Inquiry
BSGV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (IgG-Fv) Human IgG-Fv CSF1 IL34 Inquiry
BSGV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-Fv) Human IgG-Fv CSF1 IL34 Inquiry
BSDG-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fv-IgG) Human Appended IgGs CSF1 IL34 Inquiry
BSDG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fv-IgG) Human Appended IgGs CSF1 IL34 Inquiry
BABFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CSF1 IL34 Inquiry
BABFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CSF1 IL34 Inquiry
FABVC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CSF1 IL34 Inquiry
FABVC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CSF1 IL34 Inquiry
SCDBC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
SCDBC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSDBC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSDBC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
SCDBF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
SCDBF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSFVF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSFVF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSDBF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSDBF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CSF1 IL34 Inquiry
BSTF-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSTF-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSCFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSCFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
MNAB-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
MNAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSFC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSFC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSCC-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BSCC-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CSF1 IL34 Inquiry
BIBD-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Bibody) Human Bibody CSF1 IL34 Inquiry
BIBD-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Bibody) Human Bibody CSF1 IL34 Inquiry
FABFV-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Fab-Fv) Human Fab-Fv CSF1 IL34 Inquiry
FABFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-Fv) Human Fab-Fv CSF1 IL34 Inquiry
MiniB-H312 Recombinant Human Anti-CSF1 x Human Anti-IL34 Bispecific Antibody (Minibody) Human Minibody CSF1 IL34 Inquiry
MiniB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Minibody) Human Minibody CSF1 IL34 Inquiry
SCDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CSF1 IL34 Inquiry
FABIG-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-IgG) Human Fab-IgG CSF1 IL34 Inquiry
TRIB-H312 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Triple Body) Human Triple Body CSF1 IL34 Inquiry
BSIG-H310 Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-IgG) Human IgG-IgG CSF1 IL34 Inquiry
CROSSAB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (CrossMab) Human CrossMab CSF1 IL34 Inquiry
IGFV-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-scFv) Human IgG-scFv CSF1 IL34 Inquiry
BSDB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody) Human Diabody CSF1 IL34 Inquiry
BSFAB-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Fab) Human Tandem Fab CSF1 IL34 Inquiry
BSFV-H310 Recombinant Human Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv) Human Tandem scFv CSF1 IL34 Inquiry
SCDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CSF1 IL34 Inquiry
FABIG-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Fab-IgG) Human Fab-IgG CSF1 IL34 Inquiry
TRIB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Triple Body) Human Triple Body CSF1 IL34 Inquiry
BSIG-143 Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-IgG) Human IgG-IgG CSF1 IL34 Inquiry
CROSSAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (CrossMab) Human CrossMab CSF1 IL34 Inquiry
IGFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (IgG-scFv) Human IgG-scFv CSF1 IL34 Inquiry
BSDB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Diabody) Human Diabody CSF1 IL34 Inquiry
BSFAB-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem Fab) Human Tandem Fab CSF1 IL34 Inquiry
BSFV-143 Recombinant Anti-CSF1 x Anti-IL34 Bispecific Antibody (Tandem scFv) Human Tandem scFv CSF1 IL34 Inquiry

Background

CSF-1 was the first described member of the colony-stimulating factors. IL-34 was discovered in 2008 as another ligand of CSF-1R. They are essential for macrophage differentiation, particularly in steady-state microglia, Langerhans cells, and renal macrophages. Although IL-34 has little sequence similarity with CSF-1, both of them play important roles in monocyte and macrophage survival and differentiation. They have a similar structure and both bind to the same receptor, CSF-1R. They influence macrophage development by signaling through the CSF1 receptor. Combination treatments against CSF1 and IL34 are being researched as bi-specific medicines in inflammation or cancer. This might be a promising treatment strategy for macrophage-driven immunological diseases.

Fig.1 Illustration depicting IL-34 and CSF-1 receptors within tumor microenvironment featuring cancer, stromal, and immune cells. (Zins, et al., 2018) Fig.1 A schematic illustration of IL-34 and CSF-1 receptors in tumor tissue.1

Reference

  1. Zins, Karin, et al. "Differential prognostic impact of interleukin-34 mRNA expression and infiltrating immune cell composition in intrinsic breast cancer subtypes." Oncotarget 9.33 (2018): 23126.
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